September 2014 newsletter

Spark sneak peek

The next version of Spark (V10.3), Cresset’s bioisostere finder and idea generator, will be released in the next couple of weeks. In this sneak peek we take a look at a few of the exciting new features that have been requested. Read more.

Keyboard shortcuts for Spark

Building on last month’s keyboard shortcuts for Forge, take a look at and print these keyboard shortcuts for Spark. See shortcuts.

Web clips

• Ligand design using Torch and Spark in tandem – molecule growing
• Torch for iterative design

Presentations and posters presented at recent events

• Semi-quantitative SAR using Bayesian modeling on activity cliffs (EuroQSAR, oral)
• Can you keep all the SAR in your head? Using biological contexts to find the critical SAR regions (EFMC-ISMC, poster)
• Exploring synthetically accessible alternatives to P2Y12 anatagonists using electrostatics and shape (GPCRs in Medicinal Chemistry, poster)

Academic access

Any post-graduate, PhD and post-doc students enrolled in a defined degree course are entitled to free one year named user licenses for Spark, Torch and Forge. Apply for software bursary.