FieldStere
FieldStere V3.0 New Features Videos
09 November 2011
FieldStere V3.0 includes some major changes and we’re pretty excited to share them with you. Take a look at the video demonstrations below for a brief introduction to comparing multiple molecules, interacting with the improved interface and using the new database updater in FieldStere V3.0 If you have trouble viewing these videos here, please click [...]
FieldStere V3.0 Example 2: Fragment Growing
04 November 2011
FieldStere V3.0 includes several improvements to the scientific capabilities of the software. In this second example of FieldStere’s updated abilities, we look at how fragment growing can be used with Mitogen-activated Protein Kinases (P38) to generate novel, drug-like molecules. To see how FieldStere can be used in chemotype morphing, please click here. Background P38 (mitogen-activated [...]
FieldStere V3.0 Example 1: Chemotype Morphing
03 November 2011
FieldStere is a fast and powerful field based software tool which uses Cressets innovative XED technology, together with a database of molecular fragments, to help guide drug discovery projects. Typically, FieldStere is used for scaffold hopping and making bioisosteric replacement of specified parts of molecules. The latter can be done either in order to obtain [...]
Sneak Peek – FieldStere v3.0
12 October 2011
FieldStere v3.0 is scheduled for release at the end of October. This version brings additions to the scientific capabilities as well as many new and improved features to the user interface. In this version you can score molecules suggested by FieldStere against multiple other actives. This gives the software more flexibility when used on optimization [...]
Working in product space
16 March 2011
We’ve been writing an article for Current Computer-Aided Drug Design that describes many of the features of our software. As part of this we came across a nice example of the advantages of assessing bioisosteric replacements in product space rather than in fragment space. Consider the replacement of the cyclic lactone group of rofecoxib with [...]
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