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"@@վg̠>@G@YM(?8@6@6GjnD~?MWn@@??           !"#$%&'()*+,-./0123456789 : ; < = > ? @ A B C D E F G H I J K L M N OPQRSTUV W X Y Z[\]^_`abc d ef g h ij k lmnop qrst _cresset_title .JMedChem_53_4299_cmpd_6_cresset_selected _cresset_ie4 _cresset_ie3 _cresset_ie2 _cresset_ie1_cresset_energy _cresset_e4 _cresset_e3 _cresset_e2 _cresset_e1@@???g? ?7?Jx>sQJ.4M*>9.?{;@A.?gr,P?># ?n?0 ?oCJ?^z?yl?rj>n?> ? {h? ?)>o?=TRԨ?8?CV(?x? ? &8?O>0??C@,?=?$rG?}?3 @4?Ek @?b?@ k>a d?-x"@?(6MZ?@ν3?k4ht@FI?#j:<ݑL@@ =>ڼ.w;E?xfU?>.)=@@3@4/>tA=@n?$2@ JA?Fp=},/@ gz+c@U0?{>dHP?tmn@w2?O3?@=M1@qȆ?D(ƿ&>x=M1@MJ2?uV?=2_@?RN(|?4@y=2_@ݑ@z&?:>#=2_@xjZ@y@WKE@3Ɵ=н+xe? {@A)@Ec?۬n+:_?[:?F6@E]>Y=\Ct>M@9Q@Qi=:??O @@ R=:?Pq>[@`T@KZT=:?| ]I@;c@6@)8=:?Up@h@*@#m?a=:?@ @Kj@q?̭<=:?:.@!{?Z??Jx>sQ|В=Ǿ??Jx>sQ;8]h>hq;Йz?>J.4J.4 O8NCi?V6?>J.4 )_g?ž6?>J.4"?c? &'6?>J.4#:%(q?`^?>J.4YN%N<*˳@A.?g?r؈˳@A.?gqx? 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ͿGnU k>a#@!?5?6 k>a,c1?yx?(Nes>x?( Яw7?0S?( R.?)S?("ꂑ_F?+GA?(#2hLv?.?(`AG>)fss?( @@LfTwhTwh,?=7@ [QCQC,?=?E*@5I I s@%>UtkXkXƾs@su? -@A@A?0E@@?0oWp@@s B5 B5?(lU,-ks-ks?(@![hx!  k>a=UO@"G@.,?=VZ@b?(OII@w2?.:@u\ >o~h?^^?0_z@dig k>a?χfq@Pu??ɾs@ F?GMMþs=Lr?k"H!H!?k4ht@4@?2 f@@xe? {@h>a{?s:ff k>aWTG꽦l@U0?[Gtt@w2?@@[;K䰿QeQexe? {@)@/@9QQ:_?[:?h@B&VR;E?xf0Fh?y >@F@F?^z?x>6f?Ē@d@d@U0?@ ?Ԭ@@ @48? @@>o@L͌@J^>#@Y@Y;E?xfoN ?MN@@?k4ht           !"#!$!%!&"'"(")*+,-./0123456789:;<=>? @ A B C D E F G H I J K L M N O P Q R S T UVWXYZ[\ ] ^ _ `abc!de fghi j klmn o p qr!s tuv!w"xyz{ |}~ _cresset_title 0JMedChem_53_4299_cmpd_10_cresset_selected _cresset_ie4 _cresset_ie3 _cresset_ie2 _cresset_ie1_cresset_energy _cresset_e4 _cresset_e3 _cresset_e2 _cresset_e1@@???j{~ ? ?0ݒNS>U&?|>H7ur+?>!?op`9p?<~>?od}1?riL>1?޿(b n^? ?|?a?>VR(?.?Nc8?W(?w8?d? v?|q4?MA̬? ?3@ζID?)ſG??m9`@5?EK=?)h@>@u")?$V?>?Ł@=?'?kJ@?~ bd?-s2@??/MR?@D3?30@ @Fƿi?#@A\C?F>Qu=("(@4.>ׇ=@w H#?Fu=},8? 0@"RWHj?tT=},8?,@(wlоR~=},8@@AF@aCX=Cb @_|@dN'0?S=C ,@Y.@\D??t=C r@FE'P>JUkO?p<V?W=l?b꽥R?x`Dj8 ѿ `?aF~@ b!@B?1h@=>?؃|1mӭ|??N,=>?p=`I{^?8B@DAf2?D|~@B$mWx&?R@ M^60=X?bK0GO/T=<?T|  L=?=<@#&zB! ?=<@Pdx_"F @*=<@c:.W5>#=<@Lzz:?=<@bb*0>*P=>@'}-|@ =>?2L@ @cM>2=Cl d?4?{þ;={;Կ]8>h=pФD>0ݒ0ݒ O7mNR?C l>0ݒ )]˿g0ݒ"?h?' l>0ݒ#:%ڿ(?]^>0ݒ毽N<Ⱦ;5>H7u?r奾;5>H7uq?x+`9rG??h͙+`9$?X': I?!?k:?vc?w}޿(bu?nvXX|?a?>Vˆ=?+;c8?W(?= ٿNӶ?$+;c8?W(?wX??ڶ14?MA?wb?/=14?MAԌ=?x?M؝FζID;?v>Ql؝FζID ?%>ecζID >H??|AcζID"T ?Պ=>W(cζID#53?c2?e`.ζID?sK>1ǿR9`@5? ?OR9`@5?E =}>WKf>@u?D<>?v%Kf>@u >C?*3>@u ?6?(K>@u"?_S%O?,p˿#>@u#?3^0?'cgZ>@u/(?bʾה>?Ł+AK>1eה>?Ł-Rc]?yx??M=e,>ݑx?? 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R0?)U_??"ꂜ_I9?+GDQ??#1hM?.)??8z8m@??>D'B@Vl?ಔ\]\]ζID=ʊ@@>ζID?*>EXEX>@u?~r@:&)&)>@uC O>0ݒ(?o?[F?[F?30@ @%>{c>@6@6@A\C@xgR>^@ W@ Wؾ`9kܿ--X & &|?aF|&-οb.!T.!T>0ݒK@J4@H,ff?x`Dj8-?ʚ $ $?x`Dj8 e/@to C C|?a>:<@Aaj``ζID@ !?++>@u@_>>񙿳@A\C>U4@j@,ζID/"$d@J.((???ͦW@QLUUԾ>@u>Op?oHP HP ?30@ @ R@v Q>Q>9`@5$=e@S{g{g@ b!0HOn@ b!g"z *@DAf$:X@iֿ@DAf >@RZ0@DAf"#JYSS@B$mW j@B$m?D?Z@C@Cc8?W(0;_?xi>T@f@f ~?{՚@~ @~ @ M>e?T@ b@ bζIDnWF?K>@?@AB C D E F G H I J K L M N O P Q RSTUVWXY Z [ \ ]^_`abcdef g hi jk lm nop q r s!t!uvw"x yz _cresset_title 0JMedChem_53_4299_cmpd_56_cresset_selected _cresset_ie4 _cresset_ie3 _cresset_ie2 _cresset_ie1_cresset_energy _cresset_e4 _cresset_e3 _cresset_e2 _cresset_e1@@???kt8? ?_>P?|>r-&?4>*?oY쁿6?<[>H?nh>T{{?rm>~?t(?3 jB?f?BK?A{?r?>(R̘?r?s^?P(?&?w?Τ?@?[@ݼ̣??;@g?<?+G???0??EJP=?)me@@j?R )?$?$?>|@/-?.?@=?e@I `d?-u@?p0P/M?@L3?ȿ@Fֿ?"콂@ !@0r@VI?2>@=@ C?m>LV=boks@4->=@n@?L H?Fy<=},/?S޸JN(v?p=},/?LGbRH=},/?b$컈@aBtľ=C@ @K~1@dO'?T=C?$@J@\D??=C@&h@DqF'œ>?SD,=5?eHQ91  ?\M~*x6>o@͓=>5W\ӭ? ?N)=>=NCwz?4B6t.2??Dͽ~0iXd?j !*eҿ640ѻ=X khzۄ/n=<Nho h=@?Ĉ=<Yh}XA! ?Z=<ױ=ZFV@*ؾ=<rn.5) =<0e`׿z75?=< +0>=>)4/,75-Ы@ ^=>! |?0>)=ξ0>;$]>hQ=Ч^KQZR<ʿX?SЧ^KQZR O6NL.?;KQZR )]g?H;KQZR"?ȿd?Y';KQZR#:%>(?`^NKQZR熽NQ<`+?r㊾+q\?#쁿6r??hѨ#쁿6%4?VܼL޾h>T{ I?"?kh>T{e?vd?w|6t(?3uM?n"P#XvG?A{?r?>VZ=2.>?P(?&?=,N?B>?P(?&?w? "?Җ[@ݼ?w?6=IܾҖ[@ݼ??Nөg?<Y?n>Q%өg?< ?D?cg?< >H??mTcg?<"T?Չ>&cg?<#?`?V/]|g?<?ta>G|S?0??9?|S?0??E&=ń>aO @j?R ?D;<;?v* @j?R >xCo?*.~@j?R ?r6~?(Ɯ~@j?R "?_RO ?,vf#~@j?R #?3`0?'glZ@j?R 2(?cל??>|G+B>1hל??>|@:v?2?i[bޜ=?e@I@#?O=ݾޜ=?e@I @(?E?jJ=?e@I @ W2?j>FD=?e@I-9c?ylx?p0PLve^>9x?p0P Яw?0Uv?p0P R/y?)VUv?p0P"j_Hk?+ƿGDr?p0P#2hNa?.Y?p0P@VTy?]?dR=@ @V??O=R=@ @Lk?ic>W׭=@ @`'?A?nW׭=@ "@e c?օ>W׭=@ #@Pb ?D>=@ ;Cs@c]c]?p0P@@E>H((=@ D'%] mxs8s8KQZR@->^  @j?R =!n%?ކ6?ކ6?P(?&@,@cJ?t&?t&=?e@IV@ze>`"@D@D쁿6@u:>T,@D@D쁿6ל=@m?$?$?P(?&+8@?r')@-@-?ȿ@0ȇp??[@ݼ[xH?IH???ȿ05PK>`  ھQ91>d@~ľ@@g?<d@wu@t`  ?A{?r>B@>{N{{g?<>!@?Dٿg?<@ |?r]]@j?R =1?mHO9HO9?ȿ@́>2v**=@ @-H@qݿ=?e@I@~)ELee=?e@I=@||*x60HNMq*x6"\ 336t$`@hSll6tR|00i/?@I()()?p0P@RX䜿6t"J!J::0i?C>@Q;a##@j?R 0N?x5t>G@ @ h>T{?o?@T@Tg?<n??Kt@9@9?ȿ            !!"#$%& ' (!)!*+,-./0123456789:;<=>?@ A B C D E F G H I J K L M N O P Q R S TUVWXYZ[\]^_`abc de fghijklmnopqr st u v wxy z {|}~  !  _cresset_title 0JMedChem_53_4299_cmpd_27_cresset_selected _cresset_ie4 _cresset_ie3 _cresset_ie2 _cresset_ie1_cresset_energy _cresset_e4 _cresset_e3 _cresset_e2 _cresset_e1@@???lqsbX? $?o}>>8?{SK??Rr+?>%?n1?ܴP?8>?o@?w?ro>nl?Ns? x~?? <>GR?= Rl??j*?=+?xh?? ???]i̝??F@?$b?z?"I?~??',3w?E4=?)jI@?пØl )?$?>d7`z @?>??*@Z\? 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"#$%&'()*+,-./0123456789: ; < = > ? @ A B C D E F G H I J K LMNOPQRS T U VW XYZ[\ ]^_ ` a bc def ghijkl m nop _cresset_title Untitled_cresset_selected _cresset_ie4 _cresset_ie3 _cresset_ie2 _cresset_ie1_cresset_energy _cresset_e4 _cresset_e3 _cresset_e2 _cresset_e1@@???measurementsviewpoint inputs$project-appearancegrid <?}ÿXz$ -?M ,&?Ո!Befglkj