Project Services

“Cresset has consistently delivered insightful support to our drug discovery efforts. In our experience, their knowledge, responsiveness and collaborative approach have set them apart from their competitors.”

Neil Murray, CEO, Redx Pharma Ltd

---

Led by Dr Martin Slater, the professional services division has worked on a wide variety of projects and established an excellent success rate. Each member of our highly experienced team has over 10 years of experience finding innovative solutions to difficult problems, providing you with valuable results in a timely manner. Access to Cresset services is flexible and we will work with you to create a service package that suits your needs whether you prefer a traditional service agreement, a flexible bank of pre-paid service hours through CompChem on Demand, or a combination of both.

We’d love to work with you, so please contact us to discuss your project and how we can help solve its toughest problems.

Virtual Screening

FieldScreen is a ligand-based virtual screening system that returns a set of novel bioisosteres with or without knowledge of the target’s protein structure. In this project, FieldScreen was used to discover potential lead structures that could inhibit 11β-hydroxysteroid dehydrogenase type 1, which may be involved in the control of obesity, insulin resistant diabetes and cognition. The project resulted in 408 purchased structures and several patent filings for lead candidates. Read the full case study here.

Library Design

Identifying a maximum number of potentially active chemical scaffolds while ensuring the resulting compound library is tractable and cost-effective for routine screening is extremely important  in library design. In this case study, FieldTemplater was used to select a diverse library of potential H3 antagonists and the results include many novel active compounds, which couldn’t have been developed without the expert use of FieldTemplater software. Read the full case study here.

SAR Analysis & Lead Generation

This project explored the structure activity relationships (SAR) of compounds that have potential in the fight against chronic obstructive pulmonary disease (COPD), a progressive disease prevalent in industrialized countries. The analysis was used in the selection of compounds for use in virtual screening and fragment replacement experiments in order to generate new leads.  The experiments resulted in the discovery of novel chemotypes and lead candidates. Read the full case study here.

Scaffold Hopping

One of the best ways to discover new intellectual property is to perform scaffold hopping on known active compounds. In this case study, we used FieldStere to find novel structures that mimic a known allosteric antagonist (MPEP) of a metabotropic glutamate receptor. The search results contain both known actives and previously unreported active compounds, providing an excellent starting point for developing new intellectual property. Read the full case study here.

Please contact us to discuss your project today.

Previously completed projects include:

Drug Reprofiling Focused Library Design Diverse Screening Library Design Small Molecule Peptidomimetic Design Scaffold Hopping Field Based Pharmacophores SAR Analysis Protein-Protein Interactions Lead Optimization Lead Discovery Virtual Screening Structure Based Drug Design Bioisostere Detection

GPCR Class A & B Peptide Receptors Chemokines Opioid Receptors Steroid Receptors Ion Channels Proteases Matrix Metalloproteases Protein Kinases Sensing Proteins B-Amyloid Aggregation Antibodies Retinoic Acid Receptors Ubiquitin Pathways

Patent Analysis Fragment Based Virtual Screening P450s Anti-Infectives Toxicity Prediction Automated Fragment Growing Fragment Selection for Screening Novel Anti-Inflammatory Target Nuclear Receptors Design of Fragment Libraries In-Licensing Candidate Assessment Open Innovation Nematode Control Agents