Posts Tagged ‘Protein Protein Interactions’

Protein-Protein Interactions – Inhibition of β-Amyloid Aggregation

01 January 2010

Senexis Ltd had developed a series of ‘meptides’ (N-methylated peptides) that block the aggregation of β-amyloid. An example ‘L-meptide’ search molecule is shown right. Cresset was asked to use FieldScreen to find novel series of non-peptide small molecules with different physico-chemical properties from the ‘meptides’. A β-sheet conformation for four of the meptides was assumed [...]

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