Improving PROTAC properties via single-point changes to linkers
We explore how computational methods can be applied to proteolysis targeting chimera (PROTAC) design, to effectively tackle some of the ...
News
We are delighted to announce the release of a new version of Spark, our innovative tool for finding biologically equivalent replacements for key moieties in your molecule. This release contains many new features and improvements to the user interface along with new databases of bioisosteric fragments and hence is highly recommended for all users. Two key focuses for this version have been to improve the link between suggested bioisosteres and the available synthetic and property space of your project, and to make ranking Spark’s suggestions on multiple physicochemical properties easier and more intuitive.