Cresset Discovery is a new breed of CRO. This is evident in two core principles that guide our work.
The first is to use excellent in silico methods to aid small molecule discovery and design.
We believe that computational chemistry tools provide intelligent short cuts, enabling us to select ‘20% of compounds that count’ to progress to the next stage of design or optimization.
Computational techniques also give an extra level of insight to chemistry and biology. In the absence of a crystal structure, computational methods are the best way of deducing information about the protein target and the likely active conformation of the ligand.
Unlike traditional serial and parallel techniques, computational design allows for iterations, meaning that conclusions can influence thinking and the next stage of experimental design.
The second principle that informs our working style is our partnership approach. Our expertise is in silico work and we create synergy by working with others who are experts in their own field. While we can recommend partners, you can also ask us to act as the project manager – sub-contracting work such as procurement, X-ray crystallography, modeling and synthesis to our partners. This makes the process seamless for you as you then just have one point of contact and one invoice to process. The following examples demonstrate how this works in practice.