Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors
Journal of Medicinal Chemistry | 2017
Le Wang, John K. Pratt, Todd Soltwedel, George S. Sheppard, Steven D. Fidanze, Dachun Liu, Lisa A. Hasvold, Robert A. Mantei, James H. Holms, William J. McClellan, Michael D. Wendt, Carol Wada, Robin Frey, T. Matthew Hansen, Robert Hubbard, Chang H. Park, Leiming Li, Terrance J. Magoc, Daniel H. Albert, Xiaoyu Lin, Scott E. Warder, Peter Kovar, Xiaoli Huang, Denise Wilcox, Rongqi Wang, Ganesh Rajaraman, Andrew M. Petros, Charles W. Hutchins, Sanjay C. Panchal, Chaohong Sun, Steven W. Elmore, Yu Shen, Warren M. Kati, and Keith F. McDaniel