Resources

虚拟筛选——从CB1结合剂中筛选出对CB2具有选择性的先导化合物

本研究演示了如何分析起点并正确对虚拟筛选进行分级挑选，从而对化合物进行识别、选择和优先级排序。

Virtual screening - Identifying leads with selectivity for Cannabinoid receptor 2 from Cannabinoid 1 binders

This study demonstrates how analysis of the starting point and correct triaging of a virtual screen can be used to identify, select and prioritize compounds.

Identifying novel inhibitors against tuberculosis

Case study | 11 min read

Using the active site to generate new designs for InhA reductase inhibitors

Tuberculosis 억제제의 새로운 발견

Case study | 8 min read

활성 부위를 이용한 InhA 환원 효소 억제제의 새로운 설계

用SPARK™的生物等排体替换来解决代谢稳定性问题

Case study | 4 min read

英语

Addressing metabolic liabilities by bioisosteric replacements with Spark™

Case study | 10 min read

Metabolic stability of a compound is a key factor in drug discovery and development. Several compounds with promising pharmacological properties fail to become drugs due to poor metabolic stability profiles. ...

Spark을 이용한 생물 동배체 치환으로 대사 문제를 다루다

Case study | 8 min read

본 사례 연구는 Cresset의 생물 동배체 치환 및 골격 도약(scaffold hopping) 소프트웨어인 Spark를 이용하여 대사 안정성 문제를 다루는 데 있어 생물 동배체 치환이 얼마나 유용할 수 있는지 보여줍니다.

Pick new ligand-protein interactions from the active site with Spark™

Case study | 8 min read

In this case study we will use the new Spark docking feature of the Cresset bioisostere replacement and scaffold hopping tool to prioritize alternative R-groups picking ligand protein interactions directly ...

Spark™を利用して活性部位から新規のリガンド-蛋白質相互作用を見つける

Case study | 2 min read

Spark はCresset社の生物学的等価体(Bioisostere)置換およびスキャフォールドホッピングツールですが、新たにドッキング機能が搭載されました。本事例紹介では、GSK-3βの活性部位の構造をもとに、Sparkを利用してリガンド-蛋白質相互作用を作ることのできる代替置換基を直接見つけ、それら置換基をランクづけすることを解説します。

Spark™을 이용한 활성 자리에서 새로운 ligand-protein간 상호작용의 발견

Case study | 6 min read

본 사례에서는 Cresset사의 bioisostere 치환 및 scaffold hopping 도구인 Spark의 새로운 docking 기능을 이용하여 GSK-3β의 활성 자리에서 직접적으로 ligand-protein간 상호작용을 할 수 있는 대체 R-group을 발견하고 이들을 서열화 하는 것에 ...

从活性位点里发现新的蛋白-配体相互作用

Case study | 2 min read

在本算例中，我们使用Cresset生物等排体替换与骨架跃迁工具SPARK的对接功能，直接从GSK-3β活性位点挑选配体蛋白相互作用可供选择的R-基团替换，并进行优先排序。

Using Spark to design macrocycle BRD4 inhibitors

Case study

Macrocyclization of pharmaceutical compounds plays an increasing role in drug discovery. Macrocycles can provide several advantages such as favorable drug-like properties, and increased selectivity and binding affinity. Here we present ...

desktop

Server

Filtered by Case study, Spark™

虚拟筛选——从CB1结合剂中筛选出对CB2具有选择性的先导化合物

Virtual screening - Identifying leads with selectivity for Cannabinoid receptor 2 from Cannabinoid 1 binders

Identifying novel inhibitors against tuberculosis

Tuberculosis 억제제의 새로운 발견

用SPARK™的生物等排体替换来解决代谢稳定性问题

Addressing metabolic liabilities by bioisosteric replacements with Spark™

Spark을 이용한 생물 동배체 치환으로 대사 문제를 다루다

Pick new ligand-protein interactions from the active site with Spark™

Spark™を利用して活性部位から新規のリガンド-蛋白質相互作用を見つける

Spark™을 이용한 활성 자리에서 새로운 ligand-protein간 상호작용의 발견

从活性位点里发现新的蛋白-配体相互作用

Using Spark to design macrocycle BRD4 inhibitors

Filter resources

Request a software evaluation, Torx® demo or Discovery CRO discussion