Generate the most accurate field pharmacophores available
Working from just a few 2D structures of known active ligands, FieldTemplater (a component of Forge™) generates a series of conformations that the ligands might adopt at physiological conditions. It analyzes these conformations to find sets that show a high molecular field similarity (and hence have similar shape/binding properties). Where all the ligands with a common activity align well, it is very likely that this is the bioactive conformation. The similarities and differences in the sets provide insights into how active ligands bind to a common active site.
In cases such as GPCRs, ion channels and novel targets where the target’s structure is unavailable, FieldTemplater is the best way to reconstruct the bioactive conformation of the ligands, giving simple and easy to interpret results.