Discovery and optimization of novel small molecule HIV-1 entry inhibitors using field based virtual screening and bioisosteric replacement

With the emergence of drug resistant strains and the cumulative toxicities associated with current therapies, demand remains for new inhibitors of HIV-1 replication. The inhibition of HIV-1 entry is an attractive, yet underexploited therapeutic approach with implications for salvage and preexposure prophylactic regimens, as well as topical microbicides. Using the combination of a field-derived bioactive…

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Guiding Optimal Compound Design and Development: A One-day Symposium

19th March 2015 | Cambridge, MA, USA Cambridge, UK – 20th January 2015 – Cresset, Optibrium, Lhasa Limited and COSMOlogic, providers of chemistry software and services, are partnering to present ‘Guiding Optimal Compound Design and Development: A One-day Symposium’ on 19th March 2015 at the British Consulate General in Cambridge, MA, USA. “Chaired by Dr…

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November and December 2014 newsletter

End of year message from CEO As we near the end of the year Dr Robert Scoffin, Cresset’s CEO, looks back at how we have helped our customers deliver concrete results, the continued strengthening of the Cresset team and other key events. Read message. Release of KNIME nodes V2.3 and Pipeline Pilot components V2.3 We…

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End of year message from Dr Robert Scoffin, CEO of Cresset

As we near the end of the year it is great to look back at how we have helped our customers deliver concrete results in 2014. Commercial R&D is highly competitive and customer confidentiality is of primary importance to our customers, and therefore also to us. This makes it all the more rewarding to be…

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Release of KNIME nodes V2.3 and Pipeline Pilot components V2.3

We are delighted to announce the release of the latest versions of our components for Pipeline Pilot and nodes for KNIME. These releases update our workflow components to include functionality in the latest versions of Forge and Spark and are recommended for all users. Both the Pipeline and Pilot and KNIME components have been updated…

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