Chemistry in the fast lane
Effective ligand based virtual screening
Dramatically increase your wet screening hit rate at a fraction of the cost with a biologically intelligent search of chemical databases.
blazeV10 uses the shape and electrostatic character of known ligands to rapidly search large chemical collections for molecules with similar properties. It is excellent for replacing peptides with non-peptides and steroids with non-steroids, as well as finding novel leads from screening hits or known drug structures.
blazeV10 helps you to:
- Increase the diversity of your project’s leads and backups.
- Jump into new areas of chemical space.
- Improve the lead-like properties of hits.
- Virtually screen 10 million structures in a few hours.
- Design diverse libraries of compounds for synthesis or biological screening.
Platforms: Web, Linux, GUI, CLI. Learn more.
blazeV10 is available as software, through Cresset Consultancy Services and now through Cresset’s ‘Software as a Service‘ model.
To learn more about blazeV10, register for a free demo, or contact us for more information.
Working with blazeV10
blazeV10 searches through millions of known structures to find compounds that are likely to have similar activity regardless of structural similarity. It is installed and runs on a Linux cluster but is operated through a web-browser, enabling access from any platform and multiple locations.
Search for new leads
Above top: Cortisone, the natural ligand for 11ß-HSD1 and starting point for the blazeV10 search.
Above bottom: The diverse range of active compounds discovered by blazeV10 which have since been patented by various companies.


