Confident chemistry

Powerful new computational suite to understand SAR and design

forgeV10 gives you control and insight into your activity data enabling you to plan the direction of your project with confidence. This new technology uses the shape and electrostatic character of your molecules to create qualitative and quantitative 3D models of activity that are visually stimulating and easy to communicate to your team.

forgeV10 takes advantage of Cresset’s patented ligand comparison method to align, score and compare molecules from a biological viewpoint. Our technology has been tried and tested in hundreds of projects from virtual screening to compound design. forgeV10 brings this science to your fingertips to empower your research. Use forgeV10 to:

• Decipher complex SAR and communicate the results.
• Design better molecules based on predictions you can trust.
• Prepare detailed pharmacophores.
• Virtually screen 10 000 compounds on your desktop.
• Generate ADME and off-target activity profiles.

Platforms: Windows, Linux, Mac, CLI, Pipeline Pilot, KNIME. Learn more.

Still not sure about forgeV10?  Register for a free software demo and try it out for yourself. forgeV10 is available as software or through Cresset Consultancy Services.

Correlate field and activity data

A CCK-2 template derived from three structurally diverse ligands.  The graph shows the tight correlation between field similarity value and CCK-2 activity for seven other diverse molecules with a range of activities.

Understand how compounds interact with protein targets

Working from just a few 2D structures of known active ligands, forgeV10 generates a series of conformations that the ligands might adopt under physiological conditions. It analyzes these to find sets with a high molecular field similarity and hence with similar shape and binding properties to find the bioactive conformation.