Therapeutic protein degradation by design?
The old problem and the new paradigm Classical small molecule drug paradigms generally involve intervention at a ligand protein binding ...
What happens when virtual screening libraries meet the real world?
Virtual screening libraries can be brilliantly designed to deliver the best range of chemistry for your wet screen, but when the virtual meets the real, things get more complicated. Including computational chemistry in the procurement process means that you can move from virtual screening to plated compounds and still keep the best of both worlds.