Torx® Make – CDD Vault® integration

Integration with CDD Vault enables seamless CRO collaboration and removes manual registration steps

The Torx Make Kanban

Torx Make enables research chemists and managers to easily track and manage compound synthesis across all in-house and CRO projects. Furthermore, integration of Torx with CDD Vault, a modern web application for chemical registration, enables chemists to register compounds at the click of a button and ensure all output is automatically calculated and kept up to date across both platforms.

The visual, intuitive Kanban system of Torx Make provides users with a top-level overview of all the latest synthesis progress and information, facilitating informed decision making and allocating resource around project demands. Workflow headers can be customized to suit the needs of the customer, but will typically include 'For synthesis', 'In synthesis', 'Synthesis complete' and 'Registered' (figure 1). Users can connect seamlessly to other in-house and third-party informatics solutions to centralize all workflows and standardize data management. 

Torx Make CRO assignment

Figure 1. The Torx Make Kanban

Integration of Torx Make with CDD Vault can then be carried out very easily to facilitate seamless synthesis and registration of new compounds. There are two main pathways that the integration can follow. The choice between each pathway is very much decided by the customer, depending on which best suits their needs and working practices. In either case, Torx will accommodate customers' individual needs to offer the best possible level of support. Both scenarios offer an easy and efficient way of working with CROs.

Option A: Registration event initiated in Torx Software

Moving a compound ticket into the 'Registered' column initiates a registration trigger in Torx Make (figure 2). Business rules can be added here so that registration will only be allowed if all the required information has been entered into the compound ticket. Internal chemistry teams may also wish to incorporate a QC step, where the integrity of each compound is reviewed, perhaps by viewing information such as the certificate of analysis or purity claims. The registration event will create and assign ID details to each compound from CDD Vault, including a registration number, batch number of other details determined by the customer. The details will be automatically added to the compound ticket along with a URL link to the CDD Vault inventory.

For ease of use, compounds can be moved in bulk into the 'Registered' column, and Torx Make will prevent any potential log jams by queueing compounds to register in a controlled manner.

Torx Make integrating with CDD Vault - registration initiated in Torx

Figure 2. Registration event initiated in Torx Make

Initiating registration in Torx: working with CROs

For companies outspurcing all or part of their compound synthesis to CROs, often the CRO will QC the integrity of the synthesized compounds and transfer compound tickets to the 'Registered' column.

Option B: Registration event initiated in CDD Vault

A potential second scenario involves uploading new registrations direvtly into CDD Vault once customers have all the required information from the synthesis experiment. This import into CDD Vault will automatically trigger a scan of the compound library within Torx Make - if there is a match, the compound ticket in Torx will be moved into the 'Registered' column. This provides a visual alert and attaches the registration details and the URL link to the CDD Vault inventory within Torx.

Initiating registration in CDD Vault: working with CROs

Once synthesis has been completed, CROs will provide a file to the company to review and update CDD Vault with the new information. Alternatively, customers can grant CROs direct access to CDD Vault to update themselves to further streamline workflows.

Case Study: Monte Rosa Therapeutics

Monte Rosa Therapeutics is a Boston-based biotechnology company developing a portfolio of novel molecular glue degraders. They use Torx to coordinate synthetic chemistry efforts with CRO partners, and push synthesis information directly into the CDD Vault registration system.

The integration with in-house databases has provided additional efficiencies for our CRO partners and Monte Rosa chemists, removing manual registration steps. Torx Make readily scales with our expanding requirement to leverage more externalized chemistry

Bernhard Fasching, Vice President, Chemistry at Monte Rosa Therapeutics

Read the monte rosa case study

Torx® Make – CDD Vault® integration