Discovery CRO
As your computational chemistry CRO we will never seek to own any intellectual property from your projects
Our experts bring a unique perspective to help you remove obstacles, and save time and money, to advance your drug discovery project performance
Cresset Discovery collaborates with internal and external partners using Torx®. Design tracking viewed by project owner (left) and an external partner (right).
Expertise to accelerate your assets through the pipeline
Intelligent in silico discovery approaches are at the heart of our offering. Through our extensive computational drug discovery capabilities, we work alongside you to discover fresh ideas, remove roadblocks and add direction and insight, helping you to:
- Reach your next milestone faster and more cost effectively
- Direct your resources in the direction most likely to succeed
- Gain access to the latest in silico and AI modelling technologies
Whatever your project, we share your goals and challenges. We can help at every stage of the design-make-test-analyze cycle, from how to develop an idea, to a highly focused issue with a lead compound, or anything in-between.
We do not seek to own any intellectual property from your project; all scientific materials relating to the work belong to you.
Collaborate efficiently with your in-house and external partners.
Flexible, demand-driven resources to optimize the value of your research investment
- We will help you create a service package that suits your needs, whether that be a matter of days or a long-term collaboration
- Flexible delivery models to fit with your R&D workflow – from task-based to flexible service days
- Agile delivery – as results come in, we quickly adapt to align with the strategic direction of your research
- Use us as your long-term computational chemistry CRO, or to help navigate bottlenecks in your project
Collaboration with our dedicated team sparks new methods and ideas.
Engaging Cresset Discovery CRO to advance your small molecule design project
- Enquire-Establish-Execute-Evaluate is our tried and tested framework built on the successful delivery of over 400 discovery projects
- You can expect confidentiality and partnership from a team of expert scientists, underpinned at every stage by our core values of trust and integrity
- Request a no-risk confidential discussion with our CADD experts: this often rapidly leads to the identification of potential avenues to develop your project, which can be expanded into a project proposal upon request
Testimonials from Cresset Discovery customers
Working closely with the Cresset Discovery team we aimed to identify a putative binding pose for a lead series in published PDB coordinates that was not only consistent with the kinetically deduced MOA but explained the established SAR as well. The furnished results were able to satisfy these goals and then be applied prophetically for ligand design purposes.
Twentyeight-Seven Therapeutics, USA
We sought the scientific expertise within the Cresset Discovery team to utilize their novel field and shape-based virtual screening methods in Blaze™, and their proprietary Electrostatic Complementarity™ technique to help identify a backup series for our target effectively and efficiently. Ultimately we identified 9 novel chemotypes that were clearly distinct to those arising from docking and pharmacophore virtual screening approaches, which was an exciting outcome for us.
Dr Zara Sands, Head of CADD and Informatics, Confo Therapeutics, Belgium
Through the work presented to us I was particularly impressed with the data management and visualization within Forge, so the next step was for us to use it in-house. We will use Forge alongside our continuing consulting work with Cresset to aid in the development of our understanding of the SAR and design of future antifungal agents.
Dr Graham Sibley, Head of Chemistry, F2G, UK
We really like the powerful combination of excellent software tools and molecular design expertise which we get from working with Cresset.
Dr Graham Sibley, Head of Chemistry, F2G, UK
Cresset is a valuable partner in our drug discovery programs. Their deep knowledge of computational chemistry and its application to drug discovery is enabling us to progress multiple projects across a wide range of target classes very quickly and cost-effectively. Cresset has consistently delivered insightful support to our drug discovery efforts. In our experience, their knowledge, responsiveness and collaborative approach have set them apart from their competitors.
CEO, Pharmaceutical company, UK
Cresset Discovery’s computational experience and high standard of scientific support is ideally suited to help drive the next stage of this project.
Dr Richard Boyce, Senior Director of Research at PhoreMost
Robust science, innovative methods
As your scientific partner, we share a real interest in your research. We will always choose the right technology for your project, based on your needs and project goals.
By utilizing Cresset’s proprietary technology for ligand and structure-based drug design, and close synergy with the Cresset CADD Software and Torx® DMTA teams we’re able to offer a complete solution that combines specialist software tools with molecular design expertise, to advance your project cost-effectively.
Request a confidential discussion to find out how we can add value to your project.