Free Energy Perturbation (FEP): Another technique in the drug discovery toolbox
Introduction When I first started using CHARMM over 20 years ago as a PhD student, I regularly came across references ...
The better your library is designed, the better your chances of a successful screening hit. Given knowledge of the protein target, a focused approach to library design leads to far higher hit rates than high-throughput or random screening.
Discover how templates built by Forge can be used to screen compound collections, or fragment libraries, to help to build focused screening libraries with a high chance of success. Read our article in Genetic Engineering News (15th September 2012, Vol. 32, No. 16).